Application of a dual mechanistic approach to support bilastine dose selection for older adults

• Main Authors: Chaejin Kim (Author), Valentina Lo Re (Author), Monica Rodriguez (Author), John C. Lukas (Author), Nerea Leal (Author), Cristina Campo (Author), Aintzane García‐Bea (Author), Elena Suarez (Author), Stephan Schmidt (Author), Valvanera Vozmediano (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The objective of this study was to evaluate bilastine dosing recommendations in older adults and overcome the limitation of insufficient data from phase I studies in this underrepresented population. This was achieved by integrating bilastine physicochemical, in vitro and in vivo data in yo...