Improving Encapsulation of Hydrophilic Chloroquine Diphosphate into Biodegradable Nanoparticles: A Promising Approach against Herpes Virus Simplex-1 Infection

• Main Authors: Tábata Loíse Cunha Lima (Author), Renata de Carvalho Feitosa (Author), Emanuell dos Santos-Silva (Author), Alaine Maria dos Santos-Silva (Author), Emerson Michell da Silva Siqueira (Author), Paula Renata Lima Machado (Author), Alianda Maira Cornélio (Author), Eryvaldo Sócrates Tabosa do Egito (Author), Matheus de Freitas Fernandes-Pedrosa (Author), Kleber Juvenal Silva Farias (Author), Arnóbio Antônio da Silva-Júnior (Author)
• Format: Book
• Published: MDPI AG, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chloroquine diphosphate (CQ) is a hydrophilic drug with low entrapment efficiency in hydrophobic nanoparticles (NP). Herpes simplex virus type 1 (HSV-1) is an enveloped double-stranded DNA virus worldwide known as a common human pathogen. This study aims to develop chloroquine-loaded poly(lactic aci...