Improving Encapsulation of Hydrophilic Chloroquine Diphosphate into Biodegradable Nanoparticles: A Promising Approach against Herpes Virus Simplex-1 Infection

• Egile Nagusiak: Tábata Loíse Cunha Lima (Egilea), Renata de Carvalho Feitosa (Egilea), Emanuell dos Santos-Silva (Egilea), Alaine Maria dos Santos-Silva (Egilea), Emerson Michell da Silva Siqueira (Egilea), Paula Renata Lima Machado (Egilea), Alianda Maira Cornélio (Egilea), Eryvaldo Sócrates Tabosa do Egito (Egilea), Matheus de Freitas Fernandes-Pedrosa (Egilea), Kleber Juvenal Silva Farias (Egilea), Arnóbio Antônio da Silva-Júnior (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2018-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Chloroquine diphosphate (CQ) is a hydrophilic drug with low entrapment efficiency in hydrophobic nanoparticles (NP). Herpes simplex virus type 1 (HSV-1) is an enveloped double-stranded DNA virus worldwide known as a common human pathogen. This study aims to develop chloroquine-loaded poly(lactic aci...