Deficiency of Soluble Epoxide Hydrolase Protects Cardiac Function Impaired by LPS-Induced Acute Inflammation

• Main Authors: Victor Samokhvalov (Author), K. Lockhart Jamieson (Author), Ahmed M. Darwesh (Author), Hedieh Keshavarz-Bahaghighat (Author), Tim Y. T. Lee (Author), Matthew Edin (Author), Fred Lih (Author), Darryl C. Zeldin (Author), John M. Seubert (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity. Linoleic acid (18:2n6, LA) is an essential n-6 PUFA which is converted to arachidonic acid (20:4n6, AA) by desaturation and elongation via...