A Theoretical Physiologically‐Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition

• প্রধান লেখক: Chie Emoto (লেখক), Trevor N. Johnson (লেখক), David Hahn (লেখক), Uwe Christians (লেখক), Rita R. Alloway (লেখক), Alexander A. Vinks (লেখক), Tsuyoshi Fukuda (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2019-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Physiologically‐based pharmacokinetic (PBPK) modeling allows assessment of the covariates contributing to the large pharmacokinetic (PK) variability of tacrolimus; these include multiple physiological and biochemical differences among patients. A PBPK model of tacrolimus was developed, including a v...