A Theoretical Physiologically‐Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition

• Asıl Yazarlar: Chie Emoto (Yazar), Trevor N. Johnson (Yazar), David Hahn (Yazar), Uwe Christians (Yazar), Rita R. Alloway (Yazar), Alexander A. Vinks (Yazar), Tsuyoshi Fukuda (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2019-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Physiologically‐based pharmacokinetic (PBPK) modeling allows assessment of the covariates contributing to the large pharmacokinetic (PK) variability of tacrolimus; these include multiple physiological and biochemical differences among patients. A PBPK model of tacrolimus was developed, including a v...