A Theoretical Physiologically‐Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition

Physiologically‐based pharmacokinetic (PBPK) modeling allows assessment of the covariates contributing to the large pharmacokinetic (PK) variability of tacrolimus; these include multiple physiological and biochemical differences among patients. A PBPK model of tacrolimus was developed, including a v...

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Bibliographic Details
Main Authors: Chie Emoto (Author), Trevor N. Johnson (Author), David Hahn (Author), Uwe Christians (Author), Rita R. Alloway (Author), Alexander A. Vinks (Author), Tsuyoshi Fukuda (Author)
Format: Book
Published: Wiley, 2019-05-01T00:00:00Z.
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