Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes

• Main Authors: Congshan Jiang (Author), Jing Xu (Author), Wenhua Zhu (Author), Yongsong Cai (Author), Si Wang (Author), Yuanxu Guo (Author), Ke Xu (Author), Manman Geng (Author), Nazim Hussain (Author), Yan Han (Author), Fujun Zhang (Author), Qilan Ning (Author), Liesu Meng (Author), Shemin Lu (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysregulation of multiple microRNAs widely takes place during rheumatoid arthritis (RA) and experimental arthritides. This study is performed to explore the possible mechanism underlying DICER1 deficiency-mediated inflammation in human synoviocytes SW982. Firstly, RNAi of DICER1 led to increased COX...