Nanoparticle-Mediated Delivery of Emodin via Colonic Irrigation Attenuates Renal Injury in 5/6 Nephrectomized Rats

• Main Authors: Zhaoyu Lu (Author), Chunlan Ji (Author), Xuewen Luo (Author), Yong Lan (Author), Lijuan Han (Author), Yang Chen (Author), Xusheng Liu (Author), Qinzhan Lin (Author), Fuhua Lu (Author), Xiuqing Wu (Author), Rui Guo (Author), Chuan Zou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our previous study showed that emodin enema modulates gut microbiota and delays CKD progression. However, the poor solubility, limited colonic irrigation retention time, and inadequate colon adhesion of emodin hinder its clinical application. Based on the deficiencies of emodin, we prepared monometh...