High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene

• Main Authors: Jehnan Liu (Author), Sadeesh K. Ramakrishnan (Author), Saja S. Khuder (Author), Meenakshi K. Kaw (Author), Harrison T. Muturi (Author), Sumona Ghosh Lester (Author), Sang Jun Lee (Author), Larisa V. Fedorova (Author), Andrea J. Kim (Author), Iman E. Mohamed (Author), Cara Gatto-Weis (Author), Kathryn M. Eisenmann (Author), Philip B. Conran (Author), Sonia M. Najjar (Author)
• Format: Book
• Published: Elsevier, 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Association between prostate cancer and obesity remains controversial. Allelic deletions of PTEN, a tumor suppressor gene, are common in prostate cancer in men. Monoallelic Pten deletion in mice causes low prostatic intraepithelial neoplasia (mPIN). This study tested the effect of a hyper...