Understanding the Half-Life Extension of Intravitreally Administered Antibodies Binding to Ocular Albumin

• Үндсэн зохиолчид: Simon Hauri (Зохиогч), Paulina Jakubiak (Зохиогч), Matthias Fueth (Зохиогч), Stefan Dengl (Зохиогч), Sara Belli (Зохиогч), Rubén Alvarez-Sánchez (Зохиогч), Antonello Caruso (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2020-08-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

The burden associated with frequent injections of current intravitreal (IVT) therapeutics may be reduced by long-acting delivery strategies. Binding to serum albumin has been shown to extend the ocular half-life in rabbits, however, the underlying molecular mechanisms and translational relevance rem...