Peptide Mimetic of the S100A4 Protein Modulates Peripheral Nerve Regeneration and Attenuates the Progression of Neuropathy in Myelin Protein P0 Null Mice

• Main Authors: Mihai Moldovan (Author), Volodymyr Pinchenko (Author), Oksana Dmytriyeva (Author), Stanislava Pankratova (Author), Kåre Fugleholm (Author), Jorg Klingelhofer (Author), Elisabeth Bock (Author), Vladimir Berezin (Author), Christian Krarup (Author), Darya Kiryushko (Author)
• Format: Book
• Published: BMC, 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract We recently found that S100A4, a member of the multifunctional S100 protein family, protects neurons in the injured brain and identified two sequence motifs in S100A4 mediating its neurotrophic effect. Synthetic peptides encompassing these motifs stimulated neuritogenesis and survival in vi...