Time‐to‐Event Modeling of Peripheral Neuropathy: Platform Analysis of Eight Valine‐Citrulline‐Monomethylauristatin E Antibody-Drug Conjugates

• Main Authors: Matts Kågedal (Author), Divya Samineni (Author), William R. Gillespie (Author), Dan Lu (Author), Bernard M. Fine (Author), Sandhya Girish (Author), Chunze Li (Author), Jin Y. Jin (Author)
• Format: Book
• Published: Wiley, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peripheral neuropathy (PN) is a common long‐term debilitating toxicity of antimicrotubule agents. PN was the most frequent adverse event resulting in dose modifications and/or discontinuation of treatment for valine‐citrulline‐monomethylauristatin E antibody-drug conjugates (ADCs) developed at Genen...