Modelling three‐dimensional cancer‐associated cachexia and therapy: The molecular basis and therapeutic potential of interleukin‐6 transignalling blockade

• Main Authors: Marianna Cosentino (Author), Laura Forcina (Author), Mariam Zouhair (Author), Ludovica Apa (Author), Desirèe Genovese (Author), Caterina Boccia (Author), Emanuele Rizzuto (Author), Antonio Musarò (Author)
• Format: Book
• Published: Wiley, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Causes and mechanisms underlying cancer cachexia are not fully understood, and currently, no therapeutic approaches are available to completely reverse the cachectic phenotype. Interleukin‐6 (IL‐6) has been extensively described as a key factor in skeletal muscle physiopathology,...