Downregulation of Lung Toll-Like Receptor 4 Could Effectively Attenuate Liver Transplantation-Induced Pulmonary Damage at the Early Stage of Reperfusion

• Main Authors: Xinjin Chi (Author), Weifeng Yao (Author), Ailan Zhang (Author), Mian Ge (Author), Jun Cai (Author), Shaoli Zhou (Author), Zhengyuan Xia (Author), Gangjian Luo (Author), Ziqing Hei (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute lung injury (ALI) is a severe complication of orthotopic liver transplantation (OLT) with unclear underline mechanism. Toll-like receptor 4 (TLR4) has been identified as a key receptor mediating inflammation. We hypothesized that TLR4-mediated pulmonary inflammation may contribute to developme...