Plasma Nitrate Levels Are Related to Metabolic Syndrome and Are Not Altered by Treatment with DPP-4 Inhibitor Linagliptin: A Randomised, Placebo-Controlled Trial in Patients with Early Type 2 Diabetes Mellitus

• Main Authors: Melanie Reijrink (Author), Stefanie A. De Boer (Author), Anniek M. Van Roon (Author), Riemer H. J. A. Slart (Author), Bernadette O. Fernandez (Author), Martin Feelisch (Author), Hiddo J. L. Heerspink (Author), Harry Van Goor (Author), Jan-Luuk Hillebrands (Author), Douwe J. Mulder (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The depletion of nitrate and nitrite, stable nitric oxide (NO) end-products, promotes adipose tissue dysfunction and insulin resistance (IR). Dipeptidyl peptidase-4 (DPP-4) inhibitors have the potentially beneficial side effect of increasing NO availability. In this study, nitrate and nitrite levels...