Cathepsin K activity controls cardiotoxin‐induced skeletal muscle repair in mice

• Main Authors: Shinyu Ogasawara (Author), Xian Wu Cheng (Author), Aiko Inoue (Author), Lina Hu (Author), Limei Piao (Author), Chenglin Yu (Author), Hiroki Goto (Author), Wenhu Xu (Author), Guangxian Zhao (Author), Yanna Lei (Author), Guang Yang (Author), Kaoru Kimura (Author), Hiroyuki Umegaki (Author), Guo‐Ping Shi (Author), Masafumi Kuzuya (Author)
• Format: Book
• Published: Wiley, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cathepsin K (CatK) is a widely expressed cysteine protease that has gained attention because of its enzymatic and non‐enzymatic functions in signalling. Here, we examined whether CatK‐deficiency (CatK−/−) would mitigate injury‐related skeletal muscle remodelling and fibrosis in m...