Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer's disease

• Main Authors: Yao Chen (Author), Jie Zhu (Author), Jun Mo (Author), Hongyu Yang (Author), Xueyang Jiang (Author), Hongzhi Lin (Author), Kai Gu (Author), Yuqiong Pei (Author), Liang Wu (Author), Renxiang Tan (Author), Jing Hou (Author), Jingyi Chen (Author), Yang Lv (Author), Yaoyao Bian (Author), Haopeng Sun (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small molecule cholinesterases inhibitor (ChEI) provides an effective therapeutic strategy to treat Alzheimer's disease (AD). Currently, the discovery of new ChEI with multi-target effect is still of great importance. Herein, we report the synthesis, structure-activity relationship study and bi...