Pediatric Dosing and Body Size in Biotherapeutics

• Autori principali: Hartmut Derendorf (Autore), Rong Shi (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2010-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Although pediatric doses for biotherapeutics are often based on patients' body weight (mg/kg) or body surface area (mg/m2), linear body size dose adjustment is highly empirical. Growth and maturity are also important factors that affect the absorption, distribution, metabolism and excretion (AD...