Neoantigen-targeted TCR-engineered T cell immunotherapy: current advances and challenges

• Main Authors: Zhi Pang (Author), Man-man Lu (Author), Yu Zhang (Author), Yuan Gao (Author), Jin-jin Bai (Author), Jian-ying Gu (Author), Lu Xie (Author), Wei-zhong Wu (Author)
• Format: Book
• Published: BMC, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising approach for cancer therapy with an expectation of no significant side effects. In the human body, mature T cells are armed with an incredible diversity of T cell receptors (TCRs) that theoretically react...