Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study
Imatinib is mainly metabolised by CYP3A4 and CYP2C8 and is extensively bound to α-acid glycoprotein (AAG). A physiologically based pharmacokinetic (PBPK) model for imatinib describing the CYP3A4-mediated autoinhibition during multiple dosing in gastrointestinal stromal tumor patients with normal ren...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2023-07-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |