Predictive Dose-Based Estimation of Systemic Exposure Multiples in Mouse and Monkey Relative to Human for Antisense Oligonucleotides With 2'-O-(2-Methoxyethyl) Modifications

• Main Authors: Rosie Z Yu (Author), John S Grundy (Author), Scott P Henry (Author), Tae-Won Kim (Author), Daniel A Norris (Author), Jennifer Burkey (Author), Yanfeng Wang (Author), Andrew Vick (Author), Richard S Geary (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Evaluation of species differences and systemic exposure multiples (or ratios) in toxicological animal species versus human is an ongoing exercise during the course of drug development. The systemic exposure ratios are best estimated by directly comparing area under the plasma concentration-time curv...