Pharmacokinetics of oxiracetam and its degraded substance (HOPAA) after oral and intravenous administration in rats

• Main Authors: Xinhuan Wan (Author), Xiaohong Liu (Author), Zheng Liu (Author), Panqin Ma (Author), Feitong Zhang (Author), Xiangrong Zhang (Author), Jin Sun (Author)
• Format: Book
• Published: Elsevier, 2014-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pharmacokinetics of oxiracetam and its degraded substance (4-hydroxy-2-oxo-1-pyrrolidine acetic acid, HOPAA) after oral and intravenous administration in rats were studied using an established UPLC-MS/MS method. Three groups of rats after an overnight fasted received 10 g/kg (n = 6) oxiracetam s...