Pharmacokinetics of oxiracetam and its degraded substance (HOPAA) after oral and intravenous administration in rats

• Hoofdauteurs: Xinhuan Wan (Auteur), Xiaohong Liu (Auteur), Zheng Liu (Auteur), Panqin Ma (Auteur), Feitong Zhang (Auteur), Xiangrong Zhang (Auteur), Jin Sun (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2014-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The pharmacokinetics of oxiracetam and its degraded substance (4-hydroxy-2-oxo-1-pyrrolidine acetic acid, HOPAA) after oral and intravenous administration in rats were studied using an established UPLC-MS/MS method. Three groups of rats after an overnight fasted received 10 g/kg (n = 6) oxiracetam s...