Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer

• Những tác giả chính: Hanzhi Liang (Tác giả), Yue Zhu (Tác giả), Zhiyuan Zhao (Tác giả), Jintong Du (Tác giả), Xinying Yang (Tác giả), Hao Fang (Tác giả), Xuben Hou (Tác giả)
• Định dạng: Sách
• Được phát hành: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Cyclin-dependent kinase 2 (CDK2) regulates the progression of the cell cycle and is critically associated with tumor growth. Selective CDK2 inhibition provides a potential therapeutic benefit against certain tumors. Purines and related heterocycle (e.g., R-Roscovitine) are important scaffolds in the...