A Repurposed Drug Screen Identifies Compounds That Inhibit the Binding of the COVID-19 Spike Protein to ACE2

• Váldodahkkit: Kaleb B. Tsegay (Dahkki), Christiana M. Adeyemi (Dahkki), Edward P. Gniffke (Dahkki), D. Noah Sather (Dahkki), John K. Walker (Dahkki), Stephen E. P. Smith (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Repurposed drugs that block the interaction between the SARS-CoV-2 spike protein and its receptor ACE2 could offer a rapid route to novel COVID-19 treatments or prophylactics. Here, we screened 2,701 compounds from a commercial library of drugs approved by international regulatory agencies for their...