Research on the loading and release kinetics of the vincristine sulfate liposomes and its anti-breast cancer activity

• Main Authors: Zixu Liu (Author), Yang Liu (Author), Zixuan Wu (Author), Boyuan Liu (Author), Linxuan Zhao (Author), Tian Yin (Author), Yu Zhang (Author), Haibing He (Author), Jingxin Gou (Author), Xing Tang (Author), Song Gao (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vincristine (VCR), as a cytotoxic drug, is used clinically to treat acute lymphatic leukemia and breast cancer, and commonly used clinically as vincristine sulfate (VCRS). However, its clinical use is limited by unpredictable pharmacologic characteristics, a narrow therapeutic index, and neurotoxici...