Flavonoid derivatives treat dextran sodium sulfate-induced experimental colitis in mice by inhibiting MAPK/NF-κB pathway activation

• Main Authors: Cen Xiang (Author), Quanyuan Qiu (Author), Chunmei Zhang (Author), Yandong Leng (Author), Mengzhen Yuan (Author), Yao Rong (Author), Futao Liu (Author), Lianbo Zhao (Author), Zhen Liu (Author), Yunsong Chang (Author), Yu-Ou Teng (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Flavonoids are widely found in plants and diets and are considered to possess a variety of biological activities. Therefore, in this study, 8 novel compounds derivating from the precursor compound 1a, were designed and synthesized, and their activities against ulcerative colitis(UC) were evaluated t...