The deubiquitinating enzyme 13 retards non-alcoholic steatohepatitis via blocking inactive rhomboid protein 2-dependent pathway

• Main Authors: Minxuan Xu (Author), Jun Tan (Author), Liancai Zhu (Author), Chenxu Ge (Author), Wei Dong (Author), Xianling Dai (Author), Qin Kuang (Author), Shaoyu Zhong (Author), Lili Lai (Author), Chao Yi (Author), Qiang Li (Author), Deshuai Lou (Author), Linfeng Hu (Author), Xi Liu (Author), Gang Kuang (Author), Jing Luo (Author), Jing Feng (Author), Bochu Wang (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nowadays potential preclinical drugs for the treatment of nonalcoholic steatohepatitis (NASH) have failed to achieve expected therapeutic efficacy because the pathogenic mechanisms are underestimated. Inactive rhomboid protein 2 (IRHOM2), a promising target for treatment of inflammation-related dise...