Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation.

• Main Authors: Ran Sun (Author), Xi Zhao (Author), Zixia Wang (Author), Jing Yang (Author), Limei Zhao (Author), Bin Zhan (Author), Xinping Zhu (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Trichinella spiralis expresses paramyosin (Ts-Pmy) as a defense mechanism. Ts-Pmy is a functional protein with binding activity to human complement C8 and C9 and thus plays a role in evading the attack of the host's immune system. In the present study, the binding activity of Ts-Pmy...