SIRT6 suppresses phenylephrine-induced cardiomyocyte hypertrophy though inhibiting p300

• Main Authors: Peiye Shen (Author), Xiaojun Feng (Author), Xiaoying Zhang (Author), Xiaoyang Huang (Author), Shenglan Liu (Author), Xia Lu (Author), Jingyan Li (Author), Jia You (Author), Jing Lu (Author), Zhuoming Li (Author), Jiantao Ye (Author), Peiqing Liu (Author)
• Format: Book
• Published: Elsevier, 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SIRT6 is a member of the sirtuin family of class III histone deacetylases. It plays important roles in regulating genomic stability, metabolism, stress response and aging. Our previous study has revealed that SIRT6 attenuates myocardial hypertrophy by inhibiting NF-κB activation, but the related mol...