Activation of p38 and JNK by ROS Contributes to Deoxybouvardin-Mediated Intrinsic Apoptosis in Oxaliplatin-Sensitive and -Resistant Colorectal Cancer Cells

• Main Authors: Si Yeong Seo (Author), Sang Hoon Joo (Author), Seung-On Lee (Author), Goo Yoon (Author), Seung-Sik Cho (Author), Yung Hyun Choi (Author), Jin Woo Park (Author), Jung-Hyun Shim (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colorectal cancer (CRC) remains a global health burden, accounting for almost a million deaths annually. Deoxybouvardin (DB), a non-ribosomal peptide originally isolated from <i>Bouvardia ternifolia</i>, has been reported to possess antitumor activity; however, the detailed mechanisms un...