Soft tissue angiofibroma with atypical features
Soft tissue angiofibroma (STAF) is a benign fibrovascular neoplasm with a broad differential diagnosis including both benign and malignant tumors. This report expands the histologic spectrum of STAF with a case showing transition of conventional tumor morphology to distinct area of increased cellula...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
Elsevier,
2020-11-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Soft tissue angiofibroma (STAF) is a benign fibrovascular neoplasm with a broad differential diagnosis including both benign and malignant tumors. This report expands the histologic spectrum of STAF with a case showing transition of conventional tumor morphology to distinct area of increased cellularity and cytologic atypia with diffuse, strong desmin expression, but absent myogenin and MYO-D1 expression. Mitotic figures were rare and necrosis was absent. These features have not previously been reported in STAF. A fusion was identified between AHRR and NCOA2 genes, which is a known, recurring feature of STAF. Sixteen months following resection with negative margins, there was no evidence of recurrence. Further reports of STAF showing similar findings with longer clinical follow-up are needed to determine the clinical significance of these results. |
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| Item Description: | 2214-3300 10.1016/j.ehpc.2020.200458 |