Generation of αGal-enhanced bifunctional tumor vaccine

• Main Authors: Jian He (Author), Yu Huo (Author), Zhikun Zhang (Author), Yiqun Luo (Author), Xiuli Liu (Author), Qiaoying Chen (Author), Pan Wu (Author), Wei Shi (Author), Tao Wu (Author), Chao Tang (Author), Huixue Wang (Author), Lan Li (Author), Xiyu Liu (Author), Yong Huang (Author), Yongxiang Zhao (Author), Lu Gan (Author), Bing Wang (Author), Liping Zhong (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis and high mortality. In this study, we demonstrated a novel vaccine targeting HCC and tumor neovascular endothelial cells by fusing recombinant MHCC97H cells expressing porcine α-1,3-galactose epitopes (αGal) and endorphin...