Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α'

• 主要な著者: Jennifer Hochscherf (著者), Dirk Lindenblatt (著者), Benedict Witulski (著者), Robin Birus (著者), Dagmar Aichele (著者), Christelle Marminon (著者), Zouhair Bouaziz (著者), Marc Le Borgne (著者), Joachim Jose (著者), Karsten Niefind (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2017-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Protein kinase CK2, a member of the eukaryotic protein kinase superfamily, is associated with cancer and other human pathologies and thus an attractive drug target. The indeno[1,2-b]indole scaffold is a novel lead structure to develop ATP-competitive CK2 inhibitors. Some indeno[1,2-b]indole-based CK...