DEXAMETHASONE DOWNREGULATES EXPRESSION OF TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS (TREM)-1: EVIDENCE FOR A TNFα-RELATED EFFECT

• Main Authors: Ira eMihailidou (Author), Aimilia ePelekanou (Author), Aikaterini ePistiki (Author), Aikaterini eSpyridaki (Author), Ira-Maria eTzepi (Author), Georgia eDamoraki (Author), Evangelos J Giamarellos-Bourboulis (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives To investigate the effect of dexamethasone on triggering receptor expressed on myeloid cells-1 (TREM-1).Methods Lethal infection was induced by Pseudomonas aeruginosa in 96 mice, both wild-type and TNF-/-; mice were pre-treated either with saline or with dexamethasone/hydrocortisone. TREM...