Cathepsin S Is Involved in Th17 Differentiation Through the Upregulation of IL-6 by Activating PAR-2 after Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis

• Main Authors: Masato Dekita (Author), Zhou Wu (Author), Junjun Ni (Author), Xinwen Zhang (Author), Yicong Liu (Author), Xu Yan (Author), Hiroshi Nakanishi (Author), Ichiro Takahashi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Positive links have been found between periodontitis and numerous diseases in humans via persistent inflammation throughout the body. However, the main factors responsible for maintaining this pro-inflammatory condition are poorly understood. The spleen, the largest secondary immune organ, is a cent...