Oral lactate intensifies insulin toxicity during severe insulin-induced hypoglycemia in mice

• Main Authors: Vanessa Rodrigues Vilela (Author), Marina Masetto Antunes (Author), Vilma Aparecida Ferreira Godoi (Author), Patricia Batista Travassos (Author), Helenir Medri de Souza (Author), Roberto Barbosa Bazotte (Author)
• Format: Book
• Published: Universidade de São Paulo, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT We investigated whether oral lactate could prevent seizures and deaths in mice with severe hypoglycemia induced by a high dose of insulin. For this purpose, mice were fasted for 15 h and then given an intraperitoneal injection of regular insulin (5.0 U/kg or 10.0 U/kg). Immediately after in...