Safety, pharmacokinetics, and pharmacodynamics of ART‐648, a PDE4 inhibitor in healthy subjects: A randomized, placebo‐controlled phase I study

• Main Authors: Akira Tanaka (Author), Hiroshi Nagabukuro (Author), Kanako Kuniyeda (Author), Haruhi Ando (Author), Toshinori Higashi (Author), Hirokazu Wakuda (Author), Naoyuki Otani (Author), Hideo Kudo (Author), Masae Kuranari (Author), Hidetoshi Furuie (Author), Naoto Uemura (Author)
• Format: Book
• Published: Wiley, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Phosphodiesterase 4 (PDE4) inhibitor is associated with a broad‐spectrum anti‐inflammatory mechanism. However, securing clinically efficacious doses with sufficient safety margins remains challenging due to class specific adverse events that are often unavoidable in the clinic. ART‐648 is a...