Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling

• Main Authors: Ximin Tan (Author), Deguang Kong (Author), Zhuoli Tao (Author), Fangling Cheng (Author), Baoyuan Zhang (Author), Zaiqi Wang (Author), Qi Mei (Author), Chuang Chen (Author), Kongming Wu (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking effective targeted therapies, necessitating innovative treatment approaches. While targeting ROS proto-oncogene 1 (ROS1) with crizotinib has shown promise, resistance remains a limitation. Recent...