Targeting the NAT10/NPM1 axis abrogates PD-L1 expression and improves the response to immune checkpoint blockade therapy

• Главные авторы: Ge Qin (Автор), Fan Bai (Автор), Huabin Hu (Автор), Jianwei Zhang (Автор), Weixiang Zhan (Автор), Zehua Wu (Автор), Jianxia Li (Автор), Yang Fu (Автор), Yanhong Deng (Автор)
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• Опубликовано: BMC, 2024-01-01T00:00:00Z.
• Предметы: article
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Abstract Background PD-1/PD-L1 play a crucial role as immune checkpoint inhibitors in various types of cancer. Although our previous study revealed that NPM1 was a novel transcriptional regulator of PD-L1 and stimulated the transcription of PD-L1, the underlying regulatory mechanism remains incomple...