Targeting the NAT10/NPM1 axis abrogates PD-L1 expression and improves the response to immune checkpoint blockade therapy

• Main Authors: Ge Qin (Author), Fan Bai (Author), Huabin Hu (Author), Jianwei Zhang (Author), Weixiang Zhan (Author), Zehua Wu (Author), Jianxia Li (Author), Yang Fu (Author), Yanhong Deng (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background PD-1/PD-L1 play a crucial role as immune checkpoint inhibitors in various types of cancer. Although our previous study revealed that NPM1 was a novel transcriptional regulator of PD-L1 and stimulated the transcription of PD-L1, the underlying regulatory mechanism remains incomple...