Subchronic intranasal lipopolysaccharide exposure induces pulmonary autoimmunity and glomerulonephritis in NZBWF1 mice

• Main Authors: Lauren K. Heine (Author), Lichchavi D. Rajasinghe (Author), James G. Wagner (Author), Ryan P. Lewandowski (Author), Quan-Zhen Li (Author), Alexa L. Richardson (Author), Ashleigh N. Tindle (Author), Jenan J. Shareef (Author), Jack R. Harkema (Author), James J. Pestka (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lupus, a systemic autoimmune disease shaped by gene-environment interplay, often progresses to endstage renal failure. While subchronic systemic exposure to bacterial lipopolysaccharide (LPS) triggers autoimmunity and glomerulonephritis in lupus-prone mice, it is unknown if inhaling LPS, which is co...