Nicotine alleviates MPTP-induced nigrostriatal damage through modulation of JNK and ERK signaling pathways in the mice model of Parkinson's disease

• Main Authors: Sisi Ruan (Author), Jiqing Xie (Author), Linhai Wang (Author), Lulu Guo (Author), Yan Li (Author), Wu Fan (Author), Rongzhan Ji (Author), Zhenlin Gong (Author), Yan Xu (Author), Jian Mao (Author), Jianping Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Nicotine (Nic) has previously been proven to reduce neurodegeneration in the models of Parkinson's disease (PD). The present study is intended to investigate the detailed mechanisms related to the potential neuroprotective effects of Nic in vivo.Methods: We established a PD model...