Immortalized human myotonic dystrophy muscle cell lines to assess therapeutic compounds

• Main Authors: Ludovic Arandel (Author), Micaela Polay Espinoza (Author), Magdalena Matloka (Author), Audrey Bazinet (Author), Damily De Dea Diniz (Author), Naïra Naouar (Author), Frédérique Rau (Author), Arnaud Jollet (Author), Frédérique Edom-Vovard (Author), Kamel Mamchaoui (Author), Mark Tarnopolsky (Author), Jack Puymirat (Author), Christophe Battail (Author), Anne Boland (Author), Jean-Francois Deleuze (Author), Vincent Mouly (Author), Arnaud F. Klein (Author), Denis Furling (Author)
• Format: Book
• Published: The Company of Biologists, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant neuromuscular diseases caused by microsatellite expansions and belong to the family of RNA-dominant disorders. Availability of cellular models in which the DM mutation is expressed within its natural context is essential to faci...