Rare variants in GPR3 in POI patients: a case series with review of literature

• Main Authors: Shuting Ren (Author), Feng Zhang (Author), Lingyue Shang (Author), Xi Yang (Author), Yuncheng Pan (Author), Xiaojin Zhang (Author), Yanhua Wu (Author)
• Format: Book
• Published: BMC, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Premature ovarian insufficiency (POI) is a highly heterogeneous disease, and up to 25% of the cases can be explained by genetic causes. G protein-coupled receptor 3 (GPR3) plays an important role in oocyte arrest, and Gpr3-deficient mice exhibited POI-like phenotypes. Case presen...