The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation

• Main Authors: Jianmin Chen (Author), Silvia Oggero (Author), Chiara Cecconello (Author), Jesmond Dalli (Author), Hedayatullah Hayat (Author), Ahmad Hjiej Andaloussi (Author), Samra Sanni (Author), Thomas EN Jonassen (Author), Mauro Perretti (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: The cardio-protective and immuno-regulatory properties of RTP-026, a synthetic peptide that spans the Annexin-A1 (AnxA1) N-terminal region, were tested in rat acute myocardial infarction. Methods and results: In vitro, selective activation of formyl-peptide receptor type 2 (FPR2) by RTP-026 oc...