Discovery of aminopyridine-containing spiro derivatives as EGFR mutations inhibitors
Neratinib is an oral pan HER inhibitor, that irreversibly inhibits EGFR and HER2 and was proven to be effective against multiple EGFR mutations. In previous study, we reported spiro [indoline-3, 4'-piperidine]-2-ones as anticancer agents. In this study, we designed aminopyridine-containing spir...
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Taylor & Francis Group,
2019-01-01T00:00:00Z.
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A1234.567 |
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