Combined α2- and D2-receptor blockade activates noradrenergic and dopaminergic neurons, but extracellular dopamine in the prefrontal cortex is determined by uptake and release from noradrenergic terminals

• Autors principals: Claudia Sagheddu (Autor), Paola Devoto (Autor), Sonia Aroni (Autor), Pierluigi Saba (Autor), Marco Pistis (Autor), Gian Luigi Gessa (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Experimental and clinical evidence indicates a deficit of release and function of dopamine in schizophrenia and suggests that α2-adrenoceptor antagonists rescue dopamine deficit and improve the antipsychotic efficacy of D2-receptor antagonists. In anesthetized male rats, we investigated how the bloc...