Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice

• Main Authors: Jiani Lu (Author), Zhengshan Tang (Author), Miaomiao Xu (Author), Jianqiang Lu (Author), Fengmei Wang (Author), Xin Ni (Author), Changnan Wang (Author), Bo Yu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTObjectives The objective of this study was to investigate whether skeletal muscle cystathionine γ-lyase (CTH) contributes to high-fat diet (HFD)-induced metabolic disorders using skeletal muscle Cth knockout (CthΔskm) mice.Methods The CthΔskm mice and littermate Cth-floxed (Cthf/f) mice were...