Ivermectin treatment of Loa loa hyper-microfilaraemic baboons (Papio anubis): Assessment of microfilarial load reduction, haematological and biochemical parameters and histopathological changes following treatment.

• Main Authors: Samuel Wanji (Author), Ebanga-Echi J Eyong (Author), Nicholas Tendongfor (Author), Che J Ngwa (Author), Elive N Esuka (Author), Arnaud J Kengne-Ouafo (Author), Fabrice R Datchoua-Poutcheu (Author), Peter Enyong (Author), Dalen Agnew (Author), Rob R Eversole (Author), Adrian Hopkins (Author), Charles D Mackenzie (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Individuals with high intensity of Loa loa are at risk of developing serious adverse events (SAEs) post treatment with ivermectin. These SAEs have remained unclear and a programmatic impediment to the advancement of community directed treatment with ivermectin. The pathogenesis of these SAEs followi...