The methanol leaf extract of Picralima nitida mitigated cisplatin-induced toxicities in rats through nuclear factor kappa beta, cardiac troponin, mineralocorticoid receptor, and Nrf2 signaling pathways

• Main Authors: Adeolu Alex Adedapo (Author), Ademola Afeez Yusuf (Author), Olufunke Olubunmi Falayi (Author), Iyanuoluwa Omolola Ogunmiluyi (Author), Blessing Seun Ogunpolu (Author), Temidayo Olutayo Omobowale (Author), Ademola Adetokunbo Oyagbemi (Author), Olumuyiwa Abiola Adejumobi (Author), Oluwafemi Omoniyi Oguntibeju (Author), Momoh Audu Yakubu (Author), Fred Bayo Yakubu (Author)
• Format: Book
• Published: Shahrekord University of Medical Sciences, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Cisplatin (CP)-induced toxicity involves oxidative stress and Picralima nitida is rich in natural antioxidants hence its methanol leaf extract was used to mitigate the toxic effect of CP.Methods: Forty rats divided into four groups of 10 rats per group were used as follows: group A (no...