Biodistribution of a Radiolabeled Antibody in Mice as an Approach to Evaluating Antibody Pharmacokinetics

• المؤلفون الرئيسيون: Kevin J. H. Allen (مؤلف), Rubin Jiao (مؤلف), Mackenzie E. Malo (مؤلف), Connor Frank (مؤلف), Ekaterina Dadachova (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2018-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

(1) Background: Monoclonal antibodies are used in the treatment of multiple conditions including cancer, autoimmune disorders, and infectious diseases. One of the initial steps in the selection of an antibody candidate for further pre-clinical development is determining its pharmacokinetics in small...