Lipophilic Constituents in Salvia miltiorrhiza Inhibit Activation of the Hepatic Stellate Cells by Suppressing the JAK1/STAT3 Signaling Pathway: A Network Pharmacology Study and Experimental Validation

• Main Authors: Ya-Xin Tang (Author), Mingming Liu (Author), Long Liu (Author), Bo-Rui Zhen (Author), Tian-Tian Wang (Author), Na Li (Author), Nanning Lv (Author), Zhenyu Zhu (Author), Guoquan Sun (Author), Xiaobo Wang (Author), Si Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liver fibrosis is currently a global health challenge with no approved therapy, with the activation of hepatic stellate cells being a principal factor. Lipophilic constituents in Salvia miltiorrhiza (LS) have been reported to improve liver function and reduce the indicators of liver fibrosis for pat...